PLAC8L1

Across TCGA patient cohorts, PLAC8L1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAC8L1-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with PLAC8L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAC8L1-to-partner and partner-to-PLAC8L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PLAC8L1-low versus PLAC8L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAC8L1→partner) and Y-score (partner→PLAC8L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.257	+3.169	.018	.020	3	1
UCEC	Ku80 →	+0.257	+3.183	.047	.010	3	1
UCEC	MEK1 →	+0.413	+3.000	.040	.036	3	1
UCEC	N-Ras →	-0.135	-3.156	.038	.020	3	1
UCEC	Rab25 →	-0.521	-3.169	.004	.020	3	1
UCEC	Src_pY416 →	-0.260	-3.156	.049	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

JNK2 by PLAC8L1 expression — UCEC

Explore this box plot interactively →