PLAC8L1

Across TCGA pan-cancer cohorts, PLAC8L1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PLAC8L1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PLAC8L1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLAC8L1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.

KIRC, COAD, and PAAD are the cancer types where PLAC8L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.511	0.704	.006	57	view →
COAD	OS	Median	IV	0.467	0.820	.001	34	view →
PAAD	DFS	Quartile	All	0.477	0.193	.002	29	view →
KIRP	DFS	Quartile	III,IV	0.409	0.875	.007	27	view →
HNSC	OS	Quartile	All	0.833	0.683	.001	27	view →
BLCA	OS	Tertile	All	0.660	0.393	.013	18	view →
ACC	OS	Median	All	0.485	0.823	.020	17	view →
LUAD	OS	Tertile	II,III,IV	0.465	0.677	.008	16	view →
PRAD	DFS	Median	All	0.653	0.919	<.001	16	view →
DLBC	DFS	Median	II,III,IV	0.487	0.851	.020	9	view →
LGG	OS	Quartile	All	0.920	0.831	.007	7	view →
SKCM	DFS	Median	II,III,IV	0.198	0.390	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PLAC8L1–KIRC (DFS)

Open the KIRC breakdown →