PLAC8L1

Across TCGA cell cohorts, PLAC8L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,322 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLAC8L1-associated GO terms across cancer lineages are Regulation of RNA splicing, Regulation of centrosome cycle, and Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Each is linked with PLAC8L1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLAC8L1-to-partner and partner-to-PLAC8L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by PLAC8L1-low versus PLAC8L1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAC8L1→partner) and Y-score (partner→PLAC8L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.081	+0.384	<.001	.001	3	10
LARGE_INTESTINE	Regulation of centrosome cycle →	+0.074	+0.343	<.001	<.001	3	9
LARGE_INTESTINE	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.086	+0.353	<.001	.002	3	9
OESOPHAGUS	Negative regulation of DNA-templated transcription, elongation →	+0.100	+0.256	.007	.003	3	9
SKIN	Ribosome biogenesis →	+0.074	+0.249	.001	.001	2	10
BONE	RNA catabolic process →	+0.068	+0.614	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,322 associations by consensus.

Regulation of RNA splicing by PLAC8L1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →