PLAC8

Across TCGA patient cohorts, PLAC8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAC8-associated genes across cancer lineages are EGFR_pY1173, Shc_pY317, and VHL. Each is linked with PLAC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAC8-to-partner and partner-to-PLAC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by PLAC8-low versus PLAC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAC8→partner) and Y-score (partner→PLAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.081	+2.486	.036	.011	3	1
UCEC	Shc_pY317 →	-0.154	-2.321	.036	.034	3	1
UCEC	VHL →	-1.167	-3.584	<.001	.002	3	1
UCEC	Cyclin-D1 →	+0.157	+2.999	.044	.035	3	1
UCEC	Caspase-8 →	-0.260	-3.584	.032	.002	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1173 by PLAC8 expression — UCEC

Explore this box plot interactively →