PLAC8

Across TCGA pan-cancer cohorts, PLAC8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PLAC8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLAC8 RNA is repressed in tumor relative to normal tissue. In most cancer types PLAC8 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where PLAC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−3.420	<.001	11	view →
KIRC	Male	IV	+1.679	<.001	11	view →
LUAD	Female	III,IV	−2.060	<.001	9	view →
HNSC	All	II,III,IV	−1.488	.003	9	view →
LIHC	Male	III,IV	−2.037	<.001	8	view →
READ	All	All	−3.617	<.001	7	view →
LUSC	Male	II,III,IV	−2.386	<.001	7	view →
CHOL	Male	All	−1.056	.007	2	view →
BRCA	All	III,IV	−0.361	.036	2	view →
PRAD	All	All	−0.284	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PLAC8–COAD

Open the COAD breakdown →