PLAAT5

Across TCGA patient cohorts, PLAAT5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAAT5-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Myosin-IIa_pS1943. Each is linked with PLAAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT5-to-partner and partner-to-PLAAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLAAT5-low versus PLAAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT5→partner) and Y-score (partner→PLAAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.312	-3.459	.013	.005	3	1
UCEC	JNK2 →	+0.259	+2.834	.009	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.288	+2.335	.005	.020	3	1
UCEC	Myosin-IIa →	+0.335	+3.010	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.323	+2.817	.048	.036	3	1
UCEC	Paxillin →	+0.350	+2.820	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by PLAAT5 expression — UCEC

Explore this box plot interactively →