PLAAT5

Across TCGA pan-cancer cohorts, PLAAT5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLAAT5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PLAAT5 RNA is repressed in tumor relative to normal tissue. In most cancer types PLAAT5 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, KIRC, and BLCA are the cancer types where PLAAT5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAAT5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−1.390	<.001	11	view →
KIRC	Male	III,IV	−0.785	<.001	11	view →
BLCA	Male	All	−1.788	<.001	8	view →
LUSC	Male	II,III,IV	−1.488	<.001	7	view →
THCA	Male	All	−0.400	<.001	7	view →
BRCA	All	All	−2.338	<.001	6	view →
UCEC	All	III,IV	−1.894	<.001	6	view →
COAD	All	All	−0.702	<.001	5	view →
HNSC	All	All	−0.451	.003	5	view →
KIRP	All	II,III,IV	−0.992	<.001	4	view →
READ	All	All	−1.307	.003	3	view →
PRAD	All	All	−1.054	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLAAT5–LUAD

Open the LUAD breakdown →