PLAAT3

Across TCGA patient cohorts, PLAAT3 mutation is significantly associated with the RNA expression of many other genes, with 531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAAT3-associated genes across cancer lineages are SNRPGP7, RNU6-129P, and RNU6-172P. Each is linked with PLAAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT3-to-partner and partner-to-PLAAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by PLAAT3-low versus PLAAT3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT3→partner) and Y-score (partner→PLAAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNRPGP7 →	+0.462	+5.474	<.001	.005	3	2
LUSC	RNU6-129P →	+0.611	+5.151	<.001	.007	3	1
LUSC	RNU6-172P →	+0.529	+5.404	<.001	.005	3	1
LUSC	UBE2V1P9 →	+0.151	+5.273	.003	.006	3	1
LUSC	RN7SL302P →	+0.195	+5.038	<.001	.009	3	1
LUSC	LINC02103 →	+0.358	+5.978	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

SNRPGP7 by PLAAT3 expression — LUSC

Explore this box plot interactively →