PLAAT3

Across TCGA cell cohorts, PLAAT3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLAAT3-associated genes across cancer lineages are PRSS54, LHCGR, and MAJIN. Each is linked with PLAAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT3-to-partner and partner-to-PLAAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by PLAAT3-low versus PLAAT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT3→partner) and Y-score (partner→PLAAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.035	+3.345	<.001	.007	3	1
LARGE_INTESTINE	LHCGR →	+0.034	+3.882	<.001	.001	3	1
LARGE_INTESTINE	MAJIN →	+0.108	+3.554	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRSS54 by PLAAT3 expression — LARGE_INTESTINE

Explore this box plot interactively →