PLAA

Across TCGA pan-cancer cohorts, PLAA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLAA data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PLAA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PLAA expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where PLAA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	31	view →
PDAC	DFS	Tertile	II,III,IV	0.241	0.528	.005	21	view →
CCRCC	DFS	Tertile	II,III,IV	0.972	0.091	.020	16	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLAA–LUAD (OS)

Open the LUAD breakdown →