PLAA

Across TCGA cell cohorts, PLAA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,632 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLAA-associated GO terms across cancer lineages are Positive regulation of synaptic vesicle recycling, Centriole-centriole cohesion, and Spindle elongation. Each is linked with PLAA in more than 8 cancer types. Because this analysis shows association rather than direction, both PLAA-to-partner and partner-to-PLAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of synaptic vesicle recycling grouped by PLAA-low versus PLAA-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAA→partner) and Y-score (partner→PLAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of synaptic vesicle recycling →	+0.180	+0.874	.001	.005	3	9
LUNG_SCLC	Centriole-centriole cohesion →	+0.080	+0.517	<.001	<.001	3	9
URINARY_TRACT	Spindle elongation →	+0.183	+0.644	.002	.009	3	9
BLOOD_Leukemia	Centrosome cycle →	+0.071	+1.051	<.001	<.001	3	9
BLOOD_Leukemia	Regulation of mitotic cytokinetic process →	+0.092	+0.889	.001	.002	3	9
BLOOD_Leukemia	Positive regulation of mitotic cytokinetic process →	+0.092	+0.889	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,632 associations by consensus.

Positive regulation of synaptic vesicle recycling by PLAA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →