PLAA

Across TCGA cell cohorts, PLAA mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLAA-associated genes across cancer lineages are GJE1, LGI1, and AMELX. Each is linked with PLAA in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAA-to-partner and partner-to-PLAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJE1 grouped by PLAA-low versus PLAA-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAA→partner) and Y-score (partner→PLAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GJE1 →	+0.020	+4.643	<.001	.004	3	1
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	AMELX →	+0.045	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SYCN →	+0.051	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GJE1 by PLAA expression — LUNG_SCLC

Explore this box plot interactively →