PLA2R1

Across TCGA patient cohorts, PLA2R1 mutation is significantly associated with the RNA expression of many other genes, with 4,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2R1-associated genes across cancer lineages are WDHD1, MYH9, and CST3. Each is linked with PLA2R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2R1-to-partner and partner-to-PLA2R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDHD1 grouped by PLA2R1-low versus PLA2R1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2R1→partner) and Y-score (partner→PLA2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WDHD1 →	+0.619	+3.459	.001	.005	3	3
UCEC	MYH9 →	+0.396	+1.463	.001	.005	3	3
UCEC	CST3 →	-0.423	-2.137	.003	<.001	3	3
UCEC	XPNPEP1 →	+0.434	+1.678	<.001	<.001	3	3
COAD	CRTAM →	+0.656	+3.331	<.001	.005	3	3
UCEC	HSPA8 →	+0.610	+1.793	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,239 associations by consensus.

WDHD1 by PLA2R1 expression — COAD

Explore this box plot interactively →