PLA2R1

Across TCGA pan-cancer cohorts, PLA2R1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PLA2R1 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PLA2R1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PLA2R1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

UVM, MESO, and STAD are the cancer types where PLA2R1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.434	0.853	<.001	102	view →
MESO	OS	Median	II,III,IV	0.293	0.498	<.001	102	view →
STAD	OS	Quartile	II,III,IV	0.349	0.580	<.001	92	view →
LUSC	OS	Quartile	All	0.826	0.690	.006	31	view →
BRCA	OS	Tertile	III,IV	0.892	0.757	.010	28	view →
OV	OS	Quartile	III,IV	0.247	0.372	.009	24	view →
SARC	OS	Tertile	All	0.594	0.358	.001	19	view →
ACC	OS	Quartile	All	0.338	0.902	.003	18	view →
PAAD	OS	Tertile	All	0.304	0.636	.001	18	view →
PRAD	DFS	Tertile	All	0.895	0.723	.008	18	view →
THYM	DFS	Median	All	0.934	0.802	.008	17	view →
KIRC	OS	Median	All	0.710	0.566	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PLA2R1–UVM (OS)

Open the UVM breakdown →