PLA2R1

Across TCGA patient cohorts, PLA2R1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2R1-associated genes across cancer lineages are p27_pT157, c-Met_pY1235, and Gab2. Each is linked with PLA2R1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLA2R1-to-partner and partner-to-PLA2R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by PLA2R1-low versus PLA2R1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2R1→partner) and Y-score (partner→PLA2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p27_pT157 →	+0.212	+2.330	.001	.020	3	3
SKCM	c-Met_pY1235 →	+0.065	+1.201	.012	.026	3	3
UCEC	Gab2 →	+0.213	+2.000	.048	.009	3	2
COAD	INPP4B →	-0.442	-3.000	.008	.035	3	2
UCEC	ATM →	-0.335	-1.321	.014	.012	3	2
COAD	Caspase-7-cleavedD198 →	+1.607	+3.467	<.001	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

p27_pT157 by PLA2R1 expression — COAD

Explore this box plot interactively →