PLA2R1

Across TCGA cell cohorts, PLA2R1 mutation is significantly associated with the RNA expression of many other genes, with 2,010 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2R1-associated genes across cancer lineages are SLC5A8, TAS2R7, and FGF8. Each is linked with PLA2R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2R1-to-partner and partner-to-PLA2R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A8 grouped by PLA2R1-low versus PLA2R1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2R1→partner) and Y-score (partner→PLA2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	2
LIVER	TAS2R7 →	+0.025	+4.459	<.001	.001	3	2
LARGE_INTESTINE	FGF8 →	+0.374	+2.745	<.001	<.001	3	2
LARGE_INTESTINE	BAG2 →	+0.881	+2.459	.002	.006	3	2
LARGE_INTESTINE	FXR1 →	+0.509	+2.265	.009	.001	3	2
LARGE_INTESTINE	IVNS1ABP →	+0.591	+2.949	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,010 associations by consensus.

SLC5A8 by PLA2R1 expression — OESOPHAGUS

Explore this box plot interactively →