PLA2G6

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PLA2G6 mutation is significantly associated with the RNA expression of many other genes, with 2,938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G6-associated genes across cancer lineages are HMG20B, RNU6-751P, and RNU6-165P. Each is linked with PLA2G6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G6-to-partner and partner-to-PLA2G6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G6→partner) and Y-score (partner→PLA2G6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMHMG20B →+0.629+3.597<.001.00133
LUADRNU6-751P →+0.518+7.930<.001.00832
LUADRNU6-165P →+0.528+7.930<.001.00832
UCECCOX15 →+0.470+3.753<.001<.00132
UCECHIRIP3 →+0.336+2.534.008<.00132
UCECCCDC3 →-0.676-2.169.003.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,938 associations by consensus.

Exploration