PLA2G6

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PLA2G6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G6-associated genes across cancer lineages are ATM, eIF4E, and GAPDH. Each is linked with PLA2G6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G6-to-partner and partner-to-PLA2G6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G6→partner) and Y-score (partner→PLA2G6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.569-2.938<.001<.00133
UCECeIF4E →+0.199+2.070.006.00132
UCECGAPDH →+0.543+2.115.003.01632
UCECASNS →+0.348+1.440.005.02432
UCECCaspase-8 →-0.202-2.195.020.00932
UCEC4E-BP1 →+0.289+2.252.002.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration