Across TCGA cell cohorts, PLA2G6 mutation is significantly associated with the RNA expression of many other genes, with 419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G6-associated genes across cancer lineages are CBY1, MIOX, and PIH1D1. Each is linked with PLA2G6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G6-to-partner and partner-to-PLA2G6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G6→partner) and Y-score (partner→PLA2G6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.929	+3.330	<.001	.002	3	1
LARGE_INTESTINE	MIOX →	+0.318	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PIH1D1 →	+0.516	+3.212	.006	.006	3	1
LARGE_INTESTINE	KXD1 →	+0.395	+3.299	.005	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.531	+3.474	<.001	.003	3	1
LARGE_INTESTINE	OCIAD1 →	+0.448	+3.125	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 419 associations by consensus.

Exploration

PLA2G6 survival (RNA) · tumor vs normal (RNA) · all PLA2G6 data types