PLA2G5

Across TCGA patient cohorts, PLA2G5 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G5-associated genes across cancer lineages are YRDCP3, OR4C49P, and MIR181A2HG. Each is linked with PLA2G5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G5-to-partner and partner-to-PLA2G5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YRDCP3 grouped by PLA2G5-low versus PLA2G5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G5→partner) and Y-score (partner→PLA2G5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	YRDCP3 →	+0.033	+4.212	<.001	.007	3	2
HNSC	OR4C49P →	+0.086	+5.182	<.001	.007	3	2
UCEC	MIR181A2HG →	+0.712	+2.807	.002	.003	3	2
LUAD	OR7K1P →	+0.047	+6.197	<.001	.001	3	2
COAD	CICP18 →	+0.037	+5.602	<.001	<.001	3	2
COAD	RPS12P15 →	+0.183	+4.693	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

YRDCP3 by PLA2G5 expression — SKCM

Explore this box plot interactively →