PLA2G5

Across TCGA pan-cancer cohorts, PLA2G5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLA2G5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLA2G5 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

KIRC, LUAD, and BLCA are the cancer types where PLA2G5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.630	<.001	11	view →
LUAD	Female	III,IV	−1.075	<.001	9	view →
BLCA	Male	III,IV	−3.895	<.001	8	view →
UCEC	All	All	−1.531	<.001	8	view →
LUSC	Male	II,III,IV	−1.481	<.001	8	view →
COAD	Male	II,III,IV	−1.419	<.001	7	view →
BRCA	All	II,III,IV	−0.982	<.001	6	view →
THCA	Male	All	+1.080	.003	5	view →
READ	All	All	−1.816	.007	4	view →
PAAD	Female	All	+0.575	.024	2	view →
LIHC	Male	All	−0.511	.001	2	view →
PRAD	All	All	−0.294	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLA2G5–KIRC

Open the KIRC breakdown →