PLA2G5

Across TCGA patient cohorts, PLA2G5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with PLA2G5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G5-to-partner and partner-to-PLA2G5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLA2G5-low versus PLA2G5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G5→partner) and Y-score (partner→PLA2G5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.326	-2.459	.007	.020	3	1
UCEC	A-Raf_pS299 →	-0.138	-3.169	.017	.019	3	1
UCEC	FoxM1 →	+0.258	+2.459	.039	.020	3	1
UCEC	Gab2 →	+0.455	+3.584	.008	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-2.446	.015	.020	3	1
UCEC	MEK1 →	+0.481	+2.459	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by PLA2G5 expression — UCEC

Explore this box plot interactively →