Across TCGA patient cohorts, PLA2G4E mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4E-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and ATM. Each is linked with PLA2G4E in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4E-to-partner and partner-to-PLA2G4E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4E→partner) and Y-score (partner→PLA2G4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.246	+2.807	.007	.003	3	2
UCEC	mTOR_pS2448 →	-0.138	-2.302	.033	.034	3	2
UCEC	ATM →	-0.533	-2.308	.007	.033	3	2
UCEC	Caspase-8 →	-0.274	-3.558	.012	.002	3	2
SKCM	HER2_pY1248 →	-0.116	-1.906	.047	.016	3	2
UCEC	A-Raf_pS299 →	-0.174	-2.321	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

PLA2G4E survival (RNA) · tumor vs normal (RNA) · all PLA2G4E data types