PLA2G4E-AS1

Across TCGA pan-cancer cohorts, PLA2G4E-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PLA2G4E-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PLA2G4E-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLA2G4E-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

KIRC, LGG, and MESO are the cancer types where PLA2G4E-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.706	0.871	<.001	64	view →
LGG	DFS	Median	All	0.658	0.781	<.001	45	view →
MESO	OS	Median	All	0.266	0.650	.005	24	view →
UCS	DFS	Quartile	II,III,IV	0.702	0.325	.010	22	view →
CHOL	OS	Median	All	0.877	0.194	.004	18	view →
THYM	OS	Quartile	All	0.776	1.000	.006	17	view →
CESC	OS	Quartile	III,IV	0.772	0.431	.010	14	view →
UVM	OS	Tertile	All	0.939	0.648	.014	12	view →
KIRP	DFS	Quartile	IV	0.035	0.685	.024	10	view →
SKCM	OS	Median	All	0.810	0.914	.006	9	view →
BRCA	DFS	Quartile	II,III,IV	0.918	0.850	.031	6	view →
DLBC	DFS	Tertile	IV	0.120	0.784	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PLA2G4E-AS1–KIRC (DFS)

Open the KIRC breakdown →