PLA2G4E-AS1

Across TCGA pan-cancer cohorts, PLA2G4E-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PLA2G4E-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G4E-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLA2G4E-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where PLA2G4E-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G4E-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.122	<.001	12	view →
THCA	All	All	−0.252	<.001	10	view →
KICH	All	All	−0.088	.019	5	view →
LIHC	Male	All	+0.061	.011	3	view →
LUAD	Male	III,IV	−0.253	.038	1	view →
LUSC	Male	All	+0.230	.048	1	view →
CHOL	All	All	+0.110	.027	1	view →
READ	Female	All	+0.100	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PLA2G4E-AS1–KIRC

Open the KIRC breakdown →