PLA2G4D

Across TCGA cell cohorts, PLA2G4D mutation is significantly associated with the mutation status of many other genes, with 3,396 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G4D-associated genes across cancer lineages are MYO1D, NIPBL, and PPP1R13L. Each is linked with PLA2G4D in more than 4 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO1D grouped by PLA2G4D-low versus PLA2G4D-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MYO1D →	+3.672	+4.307	.004	.004	1	5
URINARY_TRACT	NIPBL →	+4.672	+4.672	.001	.001	1	5
LARGE_INTESTINE	PPP1R13L →	+2.321	+2.321	.003	.003	1	5
LARGE_INTESTINE	PLXNB1 →	+1.514	+2.184	.005	.005	1	5
LARGE_INTESTINE	LAMA3 →	+1.791	+2.769	<.001	<.001	1	5
OVARY	LSS →	+5.415	+5.415	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,396 associations by consensus.

MYO1D by PLA2G4D expression — URINARY_TRACT

Explore this box plot interactively →