PLA2G4C

Across TCGA patient cohorts, PLA2G4C mutation is significantly associated with the RNA expression of many other genes, with 1,626 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4C-associated genes across cancer lineages are UBE2L2, RNA5SP215, and RN7SKP286. Each is linked with PLA2G4C in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G4C-to-partner and partner-to-PLA2G4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2L2 grouped by PLA2G4C-low versus PLA2G4C-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4C→partner) and Y-score (partner→PLA2G4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	UBE2L2 →	+0.121	+3.730	<.001	.004	3	3
BRCA	RNA5SP215 →	+0.773	+6.571	<.001	.001	3	3
UCEC	RN7SKP286 →	+0.039	+3.838	<.001	<.001	3	3
UCEC	FAM177A1 →	+0.332	+2.069	.001	<.001	3	3
LIHC	MAPK6P6 →	+0.041	+4.451	.002	.006	3	2
UCEC	EIF3JP1 →	+0.148	+1.816	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,626 associations by consensus.

UBE2L2 by PLA2G4C expression — READ

Explore this box plot interactively →