PLA2G4C

Across TCGA pan-cancer cohorts, PLA2G4C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PLA2G4C’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PLA2G4C RNA is repressed in tumor relative to normal tissue. In most cancer types PLA2G4C is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, KIRC, and LIHC are the cancer types where PLA2G4C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G4C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−1.825	<.001	11	view →
KIRC	Female	All	+1.213	<.001	11	view →
LIHC	Male	II,III,IV	+1.646	<.001	8	view →
LUSC	Female	All	−1.403	<.001	8	view →
LUAD	Female	III,IV	−1.041	<.001	7	view →
UCEC	All	III,IV	−1.866	<.001	6	view →
THCA	All	All	−0.577	<.001	6	view →
KICH	Male	III,IV	−1.007	.006	5	view →
CHOL	All	All	+1.593	.013	1	view →
HNSC	Male	All	−0.670	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PLA2G4C–BLCA

Open the BLCA breakdown →