PLA2G4C

Across TCGA patient cohorts, PLA2G4C mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4C-associated genes across cancer lineages are Caspase-8, PCNA, and ATM. Each is linked with PLA2G4C in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G4C-to-partner and partner-to-PLA2G4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PLA2G4C-low versus PLA2G4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4C→partner) and Y-score (partner→PLA2G4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.232	-2.880	.006	.001	3	3
UCEC	PCNA →	+0.287	+2.523	<.001	<.001	3	2
UCEC	ATM →	-0.581	-3.000	<.001	<.001	3	2
UCEC	Bap1-c-4 →	+0.170	+2.827	.023	.001	3	2
UCEC	C-Raf →	+0.142	+1.807	.003	.004	3	2
SKCM	IRS1 →	+0.186	+3.000	.006	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-8 by PLA2G4C expression — UCEC

Explore this box plot interactively →