PLA2G4C

Across TCGA cell cohorts, PLA2G4C mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G4C-associated genes across cancer lineages are RBMY1F, MBD3L5, and NUMBL. Each is linked with PLA2G4C in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4C-to-partner and partner-to-PLA2G4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1F grouped by PLA2G4C-low versus PLA2G4C-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4C→partner) and Y-score (partner→PLA2G4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1F →	+0.065	+5.022	<.001	.002	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	NUMBL →	+0.965	+3.212	.002	.006	3	1
LARGE_INTESTINE	ZNF330 →	+0.528	+3.212	.003	.006	3	1
LARGE_INTESTINE	SRMS →	+0.812	+3.295	.007	.003	3	1
LARGE_INTESTINE	GALR3 →	+0.111	+2.646	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

RBMY1F by PLA2G4C expression — SKIN

Explore this box plot interactively →