PLA2G2D

Across TCGA pan-cancer cohorts, PLA2G2D Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PLA2G2D data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLA2G2D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLA2G2D expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, KIRP, and SKCM are the cancer types where PLA2G2D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.148	0.685	.007	18	view →
KIRP	OS	Median	All	0.101	0.688	.002	12	view →
SKCM	DFS	Median	III,IV	0.836	0.241	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PLA2G2D–HNSC (DFS)

Open the HNSC breakdown →