PLA2G2D

Across TCGA pan-cancer cohorts, PLA2G2D RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PLA2G2D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G2D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLA2G2D is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where PLA2G2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+1.429	<.001	11	view →
KIRP	Male	All	+1.559	<.001	7	view →
LUAD	All	All	+0.949	.001	7	view →
COAD	All	All	−0.861	<.001	6	view →
STAD	Female	All	+2.671	.001	5	view →
BRCA	All	All	+0.427	.018	4	view →
HNSC	All	III,IV	+0.632	.012	3	view →
THCA	All	All	−0.705	.028	2	view →
CHOL	All	II,III,IV	−0.449	.021	2	view →
PRAD	All	All	+0.383	.026	2	view →
READ	All	All	−1.469	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PLA2G2D–KIRC

Open the KIRC breakdown →