PLA2G2D

Across TCGA patient cohorts, PLA2G2D mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G2D-associated genes across cancer lineages are Gab2, MEK1, and N-Ras. Each is linked with PLA2G2D in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G2D-to-partner and partner-to-PLA2G2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PLA2G2D-low versus PLA2G2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G2D→partner) and Y-score (partner→PLA2G2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.544	+3.000	.008	.037	3	1
UCEC	MEK1 →	+0.439	+3.000	.038	.037	3	1
UCEC	N-Ras →	-0.146	-2.986	.034	.037	3	1
UCEC	p62 Lck ligand →	+0.504	+2.817	.007	.036	3	1
UCEC	Tuberin →	+0.496	+2.817	.001	.036	3	1
UCEC	4E-BP1 →	+0.417	+2.837	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Gab2 by PLA2G2D expression — UCEC

Explore this box plot interactively →