Across TCGA patient cohorts, PLA2G2A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G2A-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK_pT183_Y185. Each is linked with PLA2G2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G2A-to-partner and partner-to-PLA2G2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G2A→partner) and Y-score (partner→PLA2G2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.248	-2.321	.049	.035	3	1
UCEC	INPP4B →	-0.390	-3.000	.016	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.218	-2.308	.010	.036	3	1
UCEC	MEK1 →	+0.401	+2.321	.029	.035	3	1
UCEC	Notch1 →	+0.250	+3.459	<.001	.005	3	1
UCEC	VHL →	-0.911	-2.321	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PLA2G2A survival (RNA) · tumor vs normal (RNA) · all PLA2G2A data types