PLA2G15

Across TCGA patient cohorts, PLA2G15 mutation is significantly associated with the RNA expression of many other genes, with 1,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G15-associated genes across cancer lineages are RNU6-12P, RNU6-1147P, and RNU6-618P. Each is linked with PLA2G15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G15-to-partner and partner-to-PLA2G15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-12P grouped by PLA2G15-low versus PLA2G15-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G15→partner) and Y-score (partner→PLA2G15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-12P →	+0.329	+5.124	<.001	.008	3	2
LUSC	RNU6-1147P →	+0.412	+4.236	.002	.008	3	2
BLCA	RNU6-618P →	+0.308	+4.685	<.001	.007	3	2
BLCA	RNU7-125P →	+0.688	+4.840	<.001	.002	3	2
UCEC	RPL31P47 →	+0.205	+1.969	.001	.008	3	2
UCEC	RNU6-1213P →	+0.171	+3.214	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,362 associations by consensus.

RNU6-12P by PLA2G15 expression — HNSC

Explore this box plot interactively →