PLA2G12B

Across TCGA patient cohorts, PLA2G12B mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G12B-associated genes across cancer lineages are eIF4E, p27_pT198, and STAT3_pY705. Each is linked with PLA2G12B in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G12B-to-partner and partner-to-PLA2G12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PLA2G12B-low versus PLA2G12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G12B→partner) and Y-score (partner→PLA2G12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.240	+3.459	.023	.005	3	1
UCEC	p27_pT198 →	+0.169	+3.169	.001	.019	3	1
UCEC	STAT3_pY705 →	-0.438	-3.159	<.001	.019	3	1
UCEC	TSC1 →	-0.236	-2.960	.006	.035	3	1
UCEC	FoxM1 →	+0.280	+3.459	.031	.005	2	1
UCEC	FOXO3a →	+0.104	+2.335	.041	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by PLA2G12B expression — UCEC

Explore this box plot interactively →