PLA2G12B

Across TCGA cell cohorts, PLA2G12B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G12B-associated genes across cancer lineages are CSN1S1, RNASE9, and OR2M5. Each is linked with PLA2G12B in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G12B-to-partner and partner-to-PLA2G12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN1S1 grouped by PLA2G12B-low versus PLA2G12B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G12B→partner) and Y-score (partner→PLA2G12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSN1S1 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.025	+4.887	<.001	.009	3	1
LARGE_INTESTINE	OR2M5 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CSN1S1 by PLA2G12B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →