Across TCGA pan-cancer cohorts, PLA2G12AP2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PLA2G12AP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G12AP2 RNA is repressed in tumor relative to normal tissue. In most cancer types PLA2G12AP2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where PLA2G12AP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G12AP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.080	.001	2	view →
KIRP	All	III,IV	−0.088	.048	1	view →
THCA	All	All	−0.028	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PLA2G12AP2 RNA expression & survival · all PLA2G12AP2 data types