PKP4

Across TCGA pan-cancer cohorts, PKP4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PKP4 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PKP4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PKP4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where PKP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.982	0.436	.008	42	view →
UCEC	DFS	Median	All	0.962	0.751	<.001	20	view →
LSCC	DFS	Median	III,IV	0.919	0.435	.002	8	view →
PDAC	OS	Median	IV	0.381	0.951	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PKP4–CCRCC (DFS)

Open the CCRCC breakdown →