PKP4

Across TCGA pan-cancer cohorts, PKP4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PKP4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PKP4 RNA is repressed in tumor relative to normal tissue. In most cancer types PKP4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and STAD are the cancer types where PKP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.515	<.001	11	view →
COAD	Male	III,IV	+1.080	<.001	11	view →
STAD	Male	II,III,IV	+1.115	<.001	10	view →
KIRC	Male	III,IV	−0.926	<.001	10	view →
LIHC	Female	II,III,IV	+1.300	<.001	9	view →
LUSC	Female	All	+0.810	<.001	6	view →
UCEC	All	II,III,IV	+0.736	.016	6	view →
CHOL	All	All	+2.288	<.001	5	view →
ESCA	All	All	+0.989	.021	4	view →
READ	All	All	+0.638	.004	4	view →
HNSC	Male	III,IV	+0.526	.007	3	view →
KIRP	Male	All	−0.566	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PKP4–KICH

Open the KICH breakdown →