PKP4

Across TCGA patient cohorts, PKP4 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,277 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PKP4-associated proteins across cancer lineages are PKP4_S382, PKP4_S776, and MYO1G. Each is linked with PKP4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PKP4-to-partner and partner-to-PKP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKP4 versus PKP4_S382 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP4→partner) and Y-score (partner→PKP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PKP4_S382 →	+0.695	+0.989	<.001	<.001	3	8
UCEC	PKP4_S776 →	+1.202	+1.126	<.001	<.001	3	8
LUAD	MYO1G →	-0.457	-0.513	<.001	<.001	3	6
BRCA	PKP4_S281 →	+0.801	+0.514	<.001	<.001	3	6
LSCC	SPCS3 →	-0.448	-0.501	<.001	<.001	3	6
UCEC	THEMIS2 →	-0.521	-0.718	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,277 associations by consensus.

PKP4 vs PKP4_S382 — GBM

Explore this scatter interactively →