PKP4

Across TCGA patient cohorts, PKP4 protein abundance is significantly associated with the protein abundance of many other proteins, with 28,575 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PKP4-associated proteins across cancer lineages are PKP4_S382, ARFGEF3, and PKP4_S273. Each is linked with PKP4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PKP4-to-partner and partner-to-PKP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKP4 versus PKP4_S382 in PDAC, with a Pearson correlation of 0.59.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP4→partner) and Y-score (partner→PKP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PKP4_S382 →	+0.645	+0.349	<.001	<.001	3	8
BRCA	ARFGEF3 →	+0.712	+0.555	<.001	<.001	3	7
BRCA	PKP4_S273 →	+0.816	+0.602	<.001	<.001	3	7
UCEC	PKP4_S776 →	+1.196	+0.711	<.001	<.001	2	8
BRCA	PKP4_S281 →	+1.026	+0.613	<.001	<.001	3	7
BRCA	ARHGAP32 →	+0.490	+0.449	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,575 associations by consensus.

PKP4 vs PKP4_S382 — PDAC

Explore this scatter interactively →