PKP4

Across TCGA patient cohorts, PKP4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKP4-associated genes across cancer lineages are C-Raf, mTOR_pS2448, and Akt_pT308. Each is linked with PKP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PKP4-to-partner and partner-to-PKP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PKP4-low versus PKP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP4→partner) and Y-score (partner→PKP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.177	+2.330	.007	.020	3	4
UCEC	mTOR_pS2448 →	-0.083	-1.266	.033	.049	3	4
UCEC	Akt_pT308 →	+0.437	+1.137	.008	.008	3	3
UCEC	Caspase-8 →	-0.174	-1.558	.008	.003	3	3
SKCM	Src_pY527 →	-0.435	-1.874	.019	.049	3	2
COAD	RAD51 →	+0.144	+2.330	.042	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

C-Raf by PKP4 expression — COAD

Explore this box plot interactively →