PKP4

Across TCGA cell cohorts, PKP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,461 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PKP4-associated GO terms across cancer lineages are Positive regulation of cytokinesis, Positive regulation of cell division, and Positive regulation of organelle assembly. Each is linked with PKP4 in more than 13 cancer types. Because this analysis shows association rather than direction, both PKP4-to-partner and partner-to-PKP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytokinesis grouped by PKP4-low versus PKP4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP4→partner) and Y-score (partner→PKP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cytokinesis →	+0.166	+1.260	<.001	<.001	3	14
CNS	Positive regulation of cell division →	+0.098	+0.837	<.001	<.001	3	13
BREAST	Positive regulation of organelle assembly →	+0.056	+0.773	.001	.001	3	12
SOFT_TISSUE	Metaphase/anaphase transition of cell cycle →	+0.149	+0.781	<.001	<.001	3	12
URINARY_TRACT	Subtelomeric heterochromatin formation →	+0.145	+0.953	<.001	.003	2	13
BONE	Response to dehydroepiandrosterone →	+0.183	+0.813	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,461 associations by consensus.

Positive regulation of cytokinesis by PKP4 expression — BONE

Explore this box plot interactively →