PKP4

Across TCGA cell cohorts, PKP4 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PKP4-associated genes across cancer lineages are SPATA48, GUCA2B, and NEUROD4. Each is linked with PKP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKP4-to-partner and partner-to-PKP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by PKP4-low versus PKP4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP4→partner) and Y-score (partner→PKP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPATA48 →	+0.022	+4.772	<.001	.002	3	3
CNS	GUCA2B →	+0.039	+4.566	<.001	.001	3	2
BLOOD_Lymphoma	NEUROD4 →	+0.125	+3.714	<.001	.006	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	TXNDC8 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

SPATA48 by PKP4 expression — CNS

Explore this box plot interactively →