PKP2

Across TCGA cell cohorts, PKP2 mutation is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKP2-associated genes across cancer lineages are KRTAP1-4, BANF2, and SYT6. Each is linked with PKP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKP2-to-partner and partner-to-PKP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-4 grouped by PKP2-low versus PKP2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP2→partner) and Y-score (partner→PKP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP1-4 →	+0.106	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
LUNG_NSCLC_LUAD	SYT6 →	+0.338	+3.554	<.001	.002	3	1
LUNG_NSCLC_LUAD	ASB18 →	+0.237	+3.630	<.001	.001	3	1
LUNG_NSCLC_LUAD	LCE5A →	+0.064	+2.770	<.001	.003	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.027	+2.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

KRTAP1-4 by PKP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →