PKP2

Across TCGA pan-cancer cohorts, PKP2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PKP2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PKP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PKP2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where PKP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.372	<.001	10	view →
LUAD	Male	II,III,IV	+1.922	<.001	7	view →
LUSC	Male	II,III,IV	+2.048	<.001	6	view →
STAD	Male	All	+1.291	<.001	6	view →
BLCA	All	III,IV	+1.525	.001	5	view →
COAD	All	All	−0.503	.001	5	view →
KIRC	All	All	+0.366	.002	5	view →
ESCA	All	II,III,IV	+2.030	.033	2	view →
PAAD	All	All	+1.027	.029	2	view →
READ	All	All	−0.702	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PKP2–THCA

Open the THCA breakdown →