PKP1

Across TCGA cell cohorts, PKP1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PKP1-associated genes across cancer lineages are MROH2B, SPP2, and DEFB129. Each is linked with PKP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKP1-to-partner and partner-to-PKP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH2B grouped by PKP1-low versus PKP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP1→partner) and Y-score (partner→PKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MROH2B →	+0.063	+4.643	<.001	.005	3	2
STOMACH	SPP2 →	+0.178	+4.432	<.001	.003	3	2
BLOOD_Lymphoma	DEFB129 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.040	+5.247	<.001	.001	3	1
SOFT_TISSUE	OR4K1 →	+0.015	+4.977	<.001	.002	3	1
SOFT_TISSUE	PDILT →	+0.009	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MROH2B by PKP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →