PKNOX2

Across TCGA cell cohorts, PKNOX2 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKNOX2-associated genes across cancer lineages are FZD3, PHYH, and FBXL4. Each is linked with PKNOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKNOX2-to-partner and partner-to-PKNOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FZD3 grouped by PKNOX2-low versus PKNOX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX2→partner) and Y-score (partner→PKNOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FZD3 →	+0.891	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PHYH →	+0.703	+3.064	.006	.009	3	1
LARGE_INTESTINE	FBXL4 →	+0.561	+3.364	<.001	.002	3	1
LARGE_INTESTINE	SNX3 →	+0.568	+3.237	.001	.003	3	1
LARGE_INTESTINE	HSPH1 →	-0.986	-3.278	<.001	.006	3	1
LARGE_INTESTINE	KCNK17 →	+0.049	+2.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FZD3 by PKNOX2 expression — LARGE_INTESTINE

Explore this box plot interactively →