PKNOX2-AS1

Across TCGA pan-cancer cohorts, PKNOX2-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PKNOX2-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PKNOX2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PKNOX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

LUSC, UVM, and BLCA are the cancer types where PKNOX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	II,III,IV	0.264	0.468	<.001	99	view →
UVM	DFS	Tertile	All	0.799	0.406	.001	91	view →
BLCA	DFS	Tertile	IV	0.087	0.288	.005	69	view →
UCS	DFS	Tertile	II,III,IV	0.652	0.158	.001	64	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	39	view →
UCEC	DFS	Tertile	All	0.491	0.661	<.001	36	view →
KIRP	DFS	Tertile	All	0.774	0.923	.001	33	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	18	view →
OV	OS	Quartile	IV	0.572	0.308	.025	18	view →
THCA	OS	Tertile	II,III,IV	0.689	0.862	.038	18	view →
SKCM	OS	Tertile	IV	0.183	0.839	.014	10	view →
STAD	DFS	Tertile	All	0.308	0.427	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PKNOX2-AS1–LUSC (OS)

Open the LUSC breakdown →